Research Grants Awarded

CURE Epilepsy sees research as the key to finding cures for the epilepsies. Each year, CURE Epilepsy funds investigator-initiated grants supporting promising trends in the field and the potential for breakthroughs in a specified area.

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Quest Awards

Anaplerosis: A Potential New Dietary Therapy For Epilepsy

Karin Borges, PhD / Texas Tech University Health Sciences Center, Amarillo, TX

Dr. Borges will test, in mice, whether an anaplerotic diet can inhibit seizures.

Multidisciplinary Awards

Targeted Enhancement Of GABA Synthesis For Epilepsy Therapy

Gregory Mathews, MD, PhD / Vanderbilt University Medical Center

This one-year collaborative effort between Dr. Poulsen (a molecular virologist) and Dr. Mathews (a clinical epileptologist and basic neuroscientist) will explore the use of viral gene technology for enhancing GABA, offering the promise of new and less debilitating therapeutic options for epilepsy patients.

Quest Awards, Funded by the UCB Diamond Sponsorship Award

Dendritic HCN Channels As A Target Against Epileptogenesis And For Improving Cognitive Deficits In Temporal Lobe Epilepsy

Christophe Bernard, PhD / INSERM, Marseille, France

By boosting HCN activity in animal models of epilepsy, using specific drugs or via genetic technology, this study may lead to new approaches to controlling seizures with the potential of also restoring cognitive function.

Challenge Awards

Predictors of Cardiac Risk and Beneficial Effects of Pharmacotherapy in Epilepsy

Steven L. Bealer, PhD / University of Utah, Salt Lake City, UT

Dr. Bealer will evaluate the relationships between medications and the heart to determine which patients should be routinely evaluated for cardiac risk, and whether appropriate cardiac drug therapy reduces the risk of death.

Traumatic Brain Injury Awards

The Role Of Serum Albumin And TGF-Beta In Post-Traumatic Epileptogenesis

Daniela Kaufer, PhD / University of California Ben-Gurion University of the Negev, Israel

This two-year project aims to develop therapies that will prevent the generation of epilepsy following brain trauma.

Traumatic Brain Injury Awards

Roles Of Glutamate-Induced Astrocytic Glutamate Release In Post-Traumatic Epilepsy

Jian Kang, MD, PhD / New York Medical College, New York, NY

The goal of this two-year project is to study how glutamate release from astrocytes, the “supporting” cells of the brain, causes the development of post-traumatic epilepsy.

Traumatic Brain Injury Awards

Prevention Of Neocortical Post-Traumatic Epileptogenesis

David Prince, MD / Stanford University, Stanford, CA

In this two-year study, they will use other approaches, such as the application of a drug that acts to decrease the action of an excitatory messenger normally present.