Catalyst Award
Rodrigo Gutierrez-Quintana, MVZ, MVM, DipECVN, MRCVS / University of Glasgow
Dr. Gutierrez-Quintana’s team will now test the effects of Ant-134 in a population of dogs with naturally occurring drug-resistant epilepsy, an important step towards translating their findings into treatments for humans.
Taking Flight Award
Joanna Mattis, MD, PhD / University of Pennsylvania
Dr. Joanna Mattis will study neuromodulatory neurons which are “master regulators” that control many functions in the brain.
CURE Epilepsy Award
Nigel Pedersen, MD / Emory University
Dr. Pedersen’s team is studying whether brain regions that control sleep-wake also control seizures. For this project, the team will directly study electrical activity in parts of the brain that control sleep and wakefulness, and brain regions involved in seizures.
CURE Epilepsy Award
Asla Pitkänen, MD, PhD / University of Eastern Finland, Kuopio Campus
The goal of this project is to assess whether the most promising of these compounds, either alone or in combination with an anti-seizure treatment, will prevent the development of epilepsy in an animal model of post-traumatic epilepsy.
Taking Flight Award
Ana Beatriz DePaula-Silva, PhD / The University of Utah
In this project, Dr DePaula-Silva will study a mouse model of epilepsy caused by a viral infection to identify specific gut bacterial populations and molecules produced by the bacteria that may play a role in protecting the animals from seizure development.
Catalyst Award
Ruth Westenbroek, PhD / University of Washington
Using their genetic mouse model of DS, Dr. Westenbroek’s lab plans to test newly developed inhibitors that act on sodium channels called Nav1.6 and Nav1.2.
CURE Epilepsy Award
Stefan Barakat, MD, PhD / Erasmus University Medical Center, Rotterdam, the Netherlands
For this project, his team will use human cell models and zebrafish to develop novel therapies for epileptic encephalopathy by targeting metabolic processes implicated in these pathways.
Taking Flight Award
Ian Wenker, PhD / University of Virginia
In this study, Dr. Wenker proposes to activate specific neuronal populations of the brainstem that either inhibit or stimulate inspiratory activity (inhalation) to recover breathing.
Catalyst Award
James O. McNamara, MD / Duke University
The goal of this translational research project is to conduct key studies to advance pY816 to human clinical trials for TLE.
