CURE Award, Funded by the Maggie Loeffel Award
Walter M. St. John, PhD / Dartmouth Medical School, Lebanon, NH
This investigator will categorize changes in breathing during seizures and describe how these changes might be responsible for SUDEP.
CURE Award
Vittorio Gallo, PhD / Children’s National Medical Center/George Washington University, Washington DC
This study will investigate the transfer of progenitor cells to replace inhibitory neurons lost in patients with temporal lobe epilepsy as a means of re-establishing normal function.
CURE Award, Funded by the Rhode Island Award
Nikolaus J. Sucher, MD / Children’s Hospital & Harvard Medical School, Boston, MA
This study will investigate the molecular details of the interaction and function of selected proteins, which may suggest novel targets for the treatment of TSC and epilepsy.
CURE Award, Funded by the Falk Medical Research Trust
Heidrum Potschka, DVM / Ludwig-Maximilians-University, Munich, Germany
The aim of Dr. Potschka’s project is to test whether resistance can be overcome by downregulating the expression of the major multidrug transporter P-glycoprotein by RNA interference (RNAi).
Quest Awards, Funded by the Matthew Siravo Memorial
Nicholas Poolos, MD, PhD / University of Washington, Seattle, WA
Dr. Poolos will investigate the novel hypothesis that lamotrigine may regulate HCN channels not by direct interaction, but instead by altering the behavior of intracellular enzymes (kinases) that in turn control ion channel activity.
Multidisciplinary Awards
Scott Baraban, PhD / University of California, San Francisco, CA
This study will combine these two projects into a critical “proof-of-principle” trial aiming to determine whether transplanted GABA-progenitor cells restore normal levels of inhibition and rescue these mutant mice from developing epilepsy.
CURE Award
Geoffrey Murphy, BS, PhD / University of Michigan, Ann Arbor, MI
The experiments in this proposal are focused on the early events that occur during the development of epilepsy.
Multidisciplinary Awards
Carl Faingold, PhD / Southern Illinois University School of Medicine
This collaborative project between Dr. Faingold, an epilepsy researcher and Dr. Utsehev-Gaard, a basic neuroscientist, will determine if novel drugs acting on serotonin will block SUDEP in DBA/2 mice with lower doses and fewer side effects.
Multidisciplinary Awards, Funded by the Central New York Award, in Memory of Christopher Donalty and Kyle Coggins
Anne Anderson, MD / Baylor College of Medicine, Houston, TX
The studies will be performed as an interdisciplinary collaboration between Dr. Anderson, an epilepsy researcher, and Dr. Vatta, a cardiovascular researcher with expertise in myocardial remodeling and channelopathies.
