CURE Award
Tracy Butler, MD / Weill Medical College of Cornell University, New York, NY
This project will use Positron Emission Tomography (PET) scanning to examine inflammation in the brains of patients with uncontrolled focal epilepsy.
CURE Award, Funded by the Christopher Donalty Interdisciplinary Award
Jenna L. Rickus, PhD, / Purdue University, West Lafayette, IN
The goal of this project, which melds biology and engineering, is to develop a novel, cell-based neural prosthetic to electrically detect a seizure before it occurs and respond by stimulating transplanted cells to rapidly release GABA, thereby preventing the seizure.
CURE Award, Funded by the Maggie Loeffel Award
Walter M. St. John, PhD / Dartmouth Medical School, Lebanon, NH
This investigator will categorize changes in breathing during seizures and describe how these changes might be responsible for SUDEP.
CURE Award
Vittorio Gallo, PhD / Children’s National Medical Center/George Washington University, Washington DC
This study will investigate the transfer of progenitor cells to replace inhibitory neurons lost in patients with temporal lobe epilepsy as a means of re-establishing normal function.
CURE Award, Funded by the Rhode Island Award
Nikolaus J. Sucher, MD / Children’s Hospital & Harvard Medical School, Boston, MA
This study will investigate the molecular details of the interaction and function of selected proteins, which may suggest novel targets for the treatment of TSC and epilepsy.
CURE Award, Funded by the Falk Medical Research Trust
Heidrum Potschka, DVM / Ludwig-Maximilians-University, Munich, Germany
The aim of Dr. Potschka’s project is to test whether resistance can be overcome by downregulating the expression of the major multidrug transporter P-glycoprotein by RNA interference (RNAi).
Quest Awards, Funded by the Matthew Siravo Memorial
Nicholas Poolos, MD, PhD / University of Washington, Seattle, WA
Dr. Poolos will investigate the novel hypothesis that lamotrigine may regulate HCN channels not by direct interaction, but instead by altering the behavior of intracellular enzymes (kinases) that in turn control ion channel activity.
Multidisciplinary Awards
Scott Baraban, PhD / University of California, San Francisco, CA
This study will combine these two projects into a critical “proof-of-principle” trial aiming to determine whether transplanted GABA-progenitor cells restore normal levels of inhibition and rescue these mutant mice from developing epilepsy.
CURE Award
Geoffrey Murphy, BS, PhD / University of Michigan, Ann Arbor, MI
The experiments in this proposal are focused on the early events that occur during the development of epilepsy.
