CURE Epilepsy Award
Annaelle Devergnas, PhD / Emory University
The hypothesis for this project is that frontal seizures disrupt the normal function of the PPN, leading to changes in sleep, and that manipulating PPN activity might restore normal sleep activity.
Taking Flight Award
Gerben van Hameren, PhD / Dalhousie University
Dr. van Hameren will study the damage to mitochondria caused by spreading depolarization and whether blocking this damage with a drug can prevent the development of post-traumatic epilepsy.
CURE Epilepsy Award
Juliet Knowles, MD, PhD / Stanford School of Medicine
For this project, the team will study whether HDACIs can prevent myelin plasticity and seizure progression in a mouse model of LGS.
CURE Epilepsy Award
Gordon Buchanan, MD, PhD / University of Iowa Medicine
Dr. Buchanan’s group will examine whether a signaling molecule called serotonin drives this time-of-day vulnerability to SUDEP.
Taking Flight Award
William Tobin, PhD / The University of Vermont and State Agriculture
Dr. Tobin will test strategies to optimize cutting-edge gene and drug therapies by selectively targeting the most severely affected cells and brain networks in a mouse model of KCNT1-related epilepsy.
Catalyst Award
James Pauly, PhD / University of Kentucky
Having obtained promising initial results in mouse models, this project will now test the safety and brain distribution of this novel therapy in a canine model.
Catalyst Award
John Gledhill, PhD / Cognizance Biomarkers, LLC
The team will build upon their preliminary research showing that people with treatment-resistant epilepsy have differences in inflammation-associated proteins in the blood compared with those who do respond to treatment.
CURE Epilepsy Award
David Auerbach, PhD / SUNY Upstate Medical University
Dr. Auerbach’s team will use analytical tools that are well accepted in the cardiac field, but new to the field of epilepsy and SUDEP, to identify epilepsy patient populations at risk of cardiac arrhythmias.
Taking Flight Award
Rina Zelmann, PhD / Massachusetts General Hospital
Dr. Zelmann proposes to generate HFOs by repeated mild stimulation of the brain through the scalp, which may enhance the ability to detect HFOs.
