Prevention of Acquired Epilepsies Awards
Karen Newell-Rogers, PhD / Texas A&M University System Health Science Center
The purpose of this proposal is to determine if we can prevent PTE by selectively targeting a damaging immune response after TBI.
SUDEP, Funded by the CURE & HOPE4SUDEP
Edward Glasscock, PhD / LSU Health Sciences Center in Shreveport
The envisioned project has the potential to widen this field by applying bioengineering analytical principles to identify interactions and associations between biosignals that can be used to predict SUDEP risk.
SUDEP
Lori Isom, PhD / University of Michigan
We will test the hypothesis that genetic epilepsy patients who are at greater risk of SUDEP will exhibit a higher beating rate and higher levels of sodium current in their iPSC-cardiac heart cells compared to people who do not have epilepsy.
SUDEP
Alica Goldman, MD, PhD / Baylor College of Medicine
We will perform whole genome sequencing on DNA samples from patients that died of SUDEP, SCD, and SIDS to understand the genomic variation in cardiac, respiratory or autonomic pathways and we will use bioinformatic analyses to understand the point of overlap in these genetic networks.
CURE Award
Erik Rytting, PhD / University of Texas, Galveston
The goal of this project is to develop nanoparticles that will accumulate in the brain to treat the epilepsy and thereby reduce the amount of medication crossing the placenta and affecting the baby’s development.
Innovator Award, in Honor of CURE 365
Nicola Marchi, PhD / CNRS Delegation Regionale Languedoc Roussillon, France
We propose that a key brain vasculature receptor called PDGFRb regulates the brain’s blood flow response to seizures, and we will explore whether modulation of the receptor using specific medications can stop seizures.
Taking Flight Award
Omar Ahmed, PhD / Brown University
Our goal is to prevent seizures by helping individual brain cells self-regulate their own activity, without the need for invasive electrodes, monitoring devices or implanted batteries.
Innovator Award, Funded by the Julie's Hope Award
Antonello Mallamaci, PhD / Scuola Internazionale Superiore di Studi Avanzati, Trieste, Italy
If successful, this approach will be exploitable for scalable, personalized cures of epileptogenic gene loss.
Innovator Award
Marta Biagioli, PhD / University of Trento, Trento, Italy
This proposal aims to demonstrate how SINEUP can rescue the protein deficit and treat the disease.
