Traumatic Brain Injury Grantees
James O. McNamara, MD / Duke University Medical Center, Durham, NC
The goal of this work is to develop a closed head injury model of PTE in a mouse strain that is amenable to genetic manipulation.
Traumatic Brain Injury Grantees
Matthew Smyth, MD, / Washington University, St. Louis, MO/University of Washington, Seattle, WA
The experiments planned include the administration of direct focal cooling at the FPI site after the development of post-traumatic chronic seizures in order to evaluate the anti-seizure effect of focal cortical cooling.
Multidisciplinary Awards, Funded by the Northwestern Dance Marathon Award
Julie Blendy, PhD / University of Pennsylvania Children’s Hospital of Philadelphia
Dr. Porter, an epilepsy researcher, and Julie Blendy, a pharmacologist will examine whether one of the master regulators of neuronal survival and gene expression, CREB, is necessary for animals to develop epilepsy after brain injury.
Quest Awards
Janet Soul, MD, CM / Children’s Hospital Boston and Harvard Medical School/ Boston, MA
A medication called bumetanide shows great promise for treating newborn seizures because the drug blocks special channels present only in the brain cells of newborns.
Multidisciplinary Awards
Douglas Nordli, MD / Children’s Memorial Hospital George Washington University Medical School
Dr. Nordli’s team hopes to learn which patients go into remission, and what medications may have aided in recovery.
CURE Award
Jong M. Rho, MD / Barrow Neurological Institute, Phoenix, AZ
The major goal of this study is to evaluate brain slices prepared from human surgical specimens using a highly computerized multi-electrode recording technique, one that may provide clues as to how seizures begin and spread within the tissue, and subsequently determine if any currently available drugs can block the abnormal firing of HH cells.
Challenge Award, Funded by the Julie's Hope Award/CURE
Gabriella D’Arcangelo, PhD / Rutgers University, Piscataway, NJ
Challenge Awards
Lionel Carmant, MD / CHU-Sainte-Justine, Montreal, Canada
Dr. Camant will evaluate whether this neuroprotective treatment improved long-term outcome by performing a developmental evaluation at 24 months and another one at 30 months post-diagnosis for autism.
CURE Award
Jingqiong Kang, MD, PhD / Vanderbilt University Medical Center, Nashville, TN
This project seeks to understand the role of a particular epilepsy gene mutation (GABAA receptor subunits) in this process.
