SUDEP, Funded by the Christopher Donalty and Kyle Coggins Memorial Award
Geoffrey Pitt, MD, PhD / Duke University
We propose to test this hypothesis with new animal models, leading to the rational discovery of SUDEP candidate genes and development of diagnostic tools for identifying susceptible individuals.
SUDEP, Funded by the Rock the Block for Pediatric Epilepsy Research Award
Chris Semsarian, PhD / University of Sydney
The proposed genetic study will be of benefit to surviving family members, both in terms of earlier diagnosis, closer clinical surveillance and initiation of early therapies to prevent the occurrence of SUDEP.
SUDEP
Edward Glasscock, PhD / Louisiana State University Health Sciences Center
Fluoxetine (better known as Prozac) prevents the brain’s reuptake of the neurotransmitter serotonin, which we predict will protect against seizure-associated respiratory arrest and SUDEP.
SUDEP
Sanjay Sisodiya, PhD / University College London
We plan to examine and compare these brains in detail, and determine whether there are differences that can give us clues to the cause of SUDEP.
Taking Flight Award
Huajun Feng, MD, PhD / Massachusetts General Hospital & Harvard Medical School
The goal of this project is to use state-of-the-art neuroscience methods to explore which brain structure(s) are involved in seizure-evoked apnea and the role of several 5-HT receptors in this phenomenon.
Taking Flight Award
Pascale Quilichini, PhD / INSERM, France
We will use high-density electrodes to read the activity of large neuronal networks in an effort to determine whether the alterations detected might contribute to seizures and/or to cognitive deficits.
Taking Flight Award
Yangzhong Huang, MD, PhD / Duke University Medical Center
In this project, I will use biochemistry and mouse genetics to investigate the role of SFKs in epileptogenesis.
Innovator Award, Funded by the Madison Friends of CURE Award
Philip Haydon, PhD / Tufts University
Using recent technical innovations we will determine how a type of glial cell, called the astrocyte, regulates the development of epilepsy with the long term objective of targeting astrocytes to prevent epilepsy.
Innovator Award
Stephen Jones, MD, PhD / Cleveland Clinic
We propose a novel method to better identify this portion of the brain by using a unique combination of two cutting edge technologies: intracranial electrode implantation with “functional” MRI, within the operative environment.
