SUDEP
Sanjay Sisodiya, PhD / University College London
We plan to examine and compare these brains in detail, and determine whether there are differences that can give us clues to the cause of SUDEP.
Taking Flight Award
Huajun Feng, MD, PhD / Massachusetts General Hospital & Harvard Medical School
The goal of this project is to use state-of-the-art neuroscience methods to explore which brain structure(s) are involved in seizure-evoked apnea and the role of several 5-HT receptors in this phenomenon.
Taking Flight Award
Pascale Quilichini, PhD / INSERM, France
We will use high-density electrodes to read the activity of large neuronal networks in an effort to determine whether the alterations detected might contribute to seizures and/or to cognitive deficits.
Taking Flight Award
Yangzhong Huang, MD, PhD / Duke University Medical Center
In this project, I will use biochemistry and mouse genetics to investigate the role of SFKs in epileptogenesis.
Innovator Award, Funded by the Madison Friends of CURE Award
Philip Haydon, PhD / Tufts University
Using recent technical innovations we will determine how a type of glial cell, called the astrocyte, regulates the development of epilepsy with the long term objective of targeting astrocytes to prevent epilepsy.
Innovator Award
Stephen Jones, MD, PhD / Cleveland Clinic
We propose a novel method to better identify this portion of the brain by using a unique combination of two cutting edge technologies: intracranial electrode implantation with “functional” MRI, within the operative environment.
Innovator Award
Stephen Moss, PhD / Tufts University
Here we will test the ability of recently identified pharmacological agents that are able to normalize intracellular chloride levels, to terminate pharmacoresistant seizures in rodents. Collectively these studies may lead to the development of novel therapy.
Innovator Award
David Hsu, MD, PhD / University of Wisconsin Madison/Mayo Clinic
Drs. Hsu and Worrell will develop this algorithm for use in epilepsy surgery. If successful, people who undergo epilepsy surgery for refractory epilepsy will have a better chance of becoming seizure-free.
Taking Flight Award
Joy Sebe, PhD / University of California, San Francisco
To increase the speed at which these progenitor cells incorporate into the epileptic brain and to potentially boost their therapeutic efficacy, Dr. Sebe is looking for molecular cues and drugs that promote cell development.
